Assay Detail
Binding
CHEMBL868301
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Inhibition of recombinant human cathepsin H in a fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.13 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113948 | — | — | 1 | 7.75 |
| CHEMBL114161 | — | — | 1 | 7.40 |
| CHEMBL203663 | — | — | 1 | 6.72 |
| CHEMBL204605 | — | — | 1 | 6.64 |
| CHEMBL96875 | — | — | 1 | - |
| CHEMBL426308 | — | — | 1 | - |
| CHEMBL381715 | — | — | 1 | - |
| CHEMBL205173 | — | — | 1 | - |
| CHEMBL117658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113948 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL114161 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL203663 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL204605 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL96875 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL426308 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL381715 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL205173 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL117658 | — | IC50 | > | 13000.0 | nM | - |