Assay Detail
Binding
CHEMBL868539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]NDP-alpha-MSH from human cloned MC4R expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of cyclic peptides with agonist activity at melanocortin receptor-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.98 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379959 | — | — | 1 | 6.61 |
| CHEMBL264120 | — | — | 1 | 6.50 |
| CHEMBL379627 | — | — | 1 | 6.17 |
| CHEMBL211131 | — | — | 1 | 5.36 |
| CHEMBL379531 | — | — | 1 | 5.24 |
| CHEMBL210399 | — | — | 1 | - |
| CHEMBL3143817 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379959 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL264120 | — | Ki | = | 319.0 | nM | 6.50 |
| CHEMBL379627 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL211131 | — | Ki | = | 4420.0 | nM | 5.36 |
| CHEMBL379531 | — | Ki | = | 5780.0 | nM | 5.24 |
| CHEMBL210399 | — | Ki | - | — | - | |
| CHEMBL3143817 | — | Ki | - | — | - |