Assay Detail
Binding
CHEMBL868541
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Inhibition of matriptase
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 56 | 7.13 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379068 | — | — | 1 | 8.82 |
| CHEMBL378657 | — | — | 1 | 8.74 |
| CHEMBL212014 | — | — | 1 | 8.41 |
| CHEMBL378192 | — | — | 1 | 8.38 |
| CHEMBL437307 | — | — | 1 | 8.30 |
| CHEMBL379194 | — | — | 1 | 8.18 |
| CHEMBL380221 | — | — | 1 | 8.06 |
| CHEMBL3706846 | — | — | 1 | 7.89 |
| CHEMBL378643 | — | — | 1 | 7.89 |
| CHEMBL379586 | — | — | 1 | 7.85 |
| CHEMBL3706845 | — | — | 1 | 7.68 |
| CHEMBL211209 | — | — | 1 | 7.58 |
| CHEMBL211401 | — | — | 1 | 7.55 |
| CHEMBL209794 | — | — | 1 | 7.42 |
| CHEMBL211659 | — | — | 1 | 7.38 |
| CHEMBL379075 | — | — | 1 | 7.36 |
| CHEMBL379357 | — | — | 1 | 7.35 |
| CHEMBL210771 | — | — | 1 | 7.34 |
| CHEMBL438959 | — | — | 1 | 7.30 |
| CHEMBL3706847 | — | — | 1 | 7.28 |
| CHEMBL380220 | — | — | 1 | 7.28 |
| CHEMBL210244 | — | — | 1 | 7.24 |
| CHEMBL212209 | — | — | 1 | 7.21 |
| CHEMBL211367 | — | — | 1 | 7.21 |
| CHEMBL209910 | — | — | 1 | 7.19 |
| CHEMBL212310 | — | — | 1 | 7.14 |
| CHEMBL212577 | — | — | 1 | 7.12 |
| CHEMBL211811 | — | — | 1 | 7.09 |
| CHEMBL211754 | — | — | 1 | 7.08 |
| CHEMBL378830 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379068 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL378657 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL212014 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL378192 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL437307 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL379194 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL380221 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3706846 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL378643 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL379586 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3706845 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL211209 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL211401 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL209794 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL211659 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL379075 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL379357 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL210771 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL438959 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3706847 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL380220 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL210244 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL212209 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL211367 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL209910 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL212310 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL212577 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL211811 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL211754 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL378830 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL211086 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL377627 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL209963 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL212538 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL379186 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL211939 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL210189 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL208586 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL379960 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL212031 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL210815 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL212616 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL379957 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL212271 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL209586 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL379958 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL107955 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL210386 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL426501 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL377763 | — | Ki | = | 380.0 | nM | 6.42 |