Assay Detail
Binding
CHEMBL868545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of f10a
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 54 | 5.15 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209794 | — | — | 1 | 6.00 |
| CHEMBL209586 | — | — | 1 | 5.96 |
| CHEMBL209910 | — | — | 1 | 5.92 |
| CHEMBL3706844 | — | — | 1 | 5.89 |
| CHEMBL211209 | — | — | 1 | 5.89 |
| CHEMBL107955 | — | — | 1 | 5.77 |
| CHEMBL378830 | — | — | 1 | 5.75 |
| CHEMBL378192 | — | — | 1 | 5.70 |
| CHEMBL378643 | — | — | 1 | 5.66 |
| CHEMBL380220 | — | — | 1 | 5.64 |
| CHEMBL211086 | — | — | 1 | 5.64 |
| CHEMBL212209 | — | — | 1 | 5.55 |
| CHEMBL211367 | — | — | 1 | 5.55 |
| CHEMBL3706847 | — | — | 1 | 5.55 |
| CHEMBL210244 | — | — | 1 | 5.54 |
| CHEMBL377627 | — | — | 1 | 5.50 |
| CHEMBL211754 | — | — | 1 | 5.43 |
| CHEMBL3706845 | — | — | 1 | 5.40 |
| CHEMBL438959 | — | — | 1 | 5.39 |
| CHEMBL379075 | — | — | 1 | 5.34 |
| CHEMBL212538 | — | — | 1 | 5.34 |
| CHEMBL3706846 | — | — | 1 | 5.31 |
| CHEMBL212031 | — | — | 1 | 5.30 |
| CHEMBL426501 | — | — | 1 | 5.29 |
| CHEMBL209963 | — | — | 1 | 5.28 |
| CHEMBL208586 | — | — | 1 | 5.24 |
| CHEMBL377763 | — | — | 1 | 5.20 |
| CHEMBL379957 | — | — | 1 | 5.08 |
| CHEMBL210386 | — | — | 1 | 5.05 |
| CHEMBL378657 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209794 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL209586 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL209910 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3706844 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL211209 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL107955 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL378830 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL378192 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL378643 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL380220 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL211086 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL212209 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL211367 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL3706847 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL210244 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL377627 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL211754 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL3706845 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL438959 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL379075 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL212538 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3706846 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL212031 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL426501 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL209963 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL208586 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL377763 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL379957 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL210386 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL378657 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL379958 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL380221 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL379586 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL209841 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL379960 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL379068 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL212310 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL211401 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL212616 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL437307 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL379186 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL379194 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL212014 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL210189 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL379357 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL210771 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL211659 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL212577 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL212271 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL210815 | — | Ki | = | 66000.0 | nM | 4.18 |