Assay Detail
Functional
CHEMBL868595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNFalpha production in human whole blood
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.22 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377317 | — | — | 1 | 5.89 |
| CHEMBL209970 | — | — | 1 | 5.82 |
| CHEMBL211274 | — | — | 1 | 5.62 |
| CHEMBL211726 | — | — | 1 | 5.62 |
| CHEMBL212481 | — | — | 1 | 5.60 |
| CHEMBL387079 | — | — | 1 | 5.57 |
| CHEMBL212411 | — | — | 1 | 5.54 |
| CHEMBL379287 | — | — | 1 | 5.48 |
| CHEMBL208841 | — | — | 1 | 5.47 |
| CHEMBL210084 | — | — | 1 | 5.33 |
| CHEMBL377862 | — | — | 1 | 5.32 |
| CHEMBL425783 | — | — | 1 | 5.28 |
| CHEMBL380049 | — | — | 1 | 5.19 |
| CHEMBL210133 | — | — | 1 | 5.01 |
| CHEMBL379763 | — | — | 1 | 5.00 |
| CHEMBL209490 | — | — | 1 | 4.96 |
| CHEMBL377272 | — | — | 1 | 4.92 |
| CHEMBL214287 | — | — | 1 | 4.89 |
| CHEMBL425251 | — | — | 1 | 4.85 |
| CHEMBL212469 | — | — | 1 | 4.85 |
| CHEMBL211770 | — | — | 1 | 4.62 |
| CHEMBL212205 | — | — | 1 | 4.62 |
| CHEMBL211487 | — | — | 1 | 4.55 |
| CHEMBL212920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377317 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL209970 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL211274 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL211726 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL212481 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL387079 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL212411 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL379287 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL208841 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL210084 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL377862 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL425783 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL380049 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL210133 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL379763 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL209490 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL377272 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL214287 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL425251 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL212469 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL211770 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL212205 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL211487 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL212920 | — | IC50 | > | 50000.0 | nM | - |