Assay Detail
Binding
CHEMBL868602
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Inhibition of rat brain homogenate AchE
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.26 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427232 | — | — | 1 | 7.73 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | 4.0 | 1 | 7.43 |
| CHEMBL209392 | — | — | 1 | 7.43 |
| CHEMBL211520 | — | — | 1 | 7.03 |
| CHEMBL380050 | — | — | 1 | 6.70 |
| CHEMBL209924 | — | — | 1 | - |
| CHEMBL212162 | — | — | 1 | - |
| CHEMBL212111 | — | — | 1 | - |
| CHEMBL209863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427232 | — | IC50 | = | 18.75 | nM | 7.73 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL209392 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL211520 | — | IC50 | = | 93.75 | nM | 7.03 |
| CHEMBL380050 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL209924 | — | IC50 | - | — | - | |
| CHEMBL212162 | — | IC50 | - | — | - | |
| CHEMBL212111 | — | IC50 | - | — | - | |
| CHEMBL209863 | — | IC50 | - | — | - |