Assay Detail
Functional
CHEMBL868623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell line
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DOV13 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Serine/threonine-protein kinase AKT (CHEMBL2111353) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.50 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213618 | — | — | 1 | 6.50 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213618 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL388978 | STAUROSPORINE | EC50 | - | — | - |