Assay Detail
Binding
CHEMBL868637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human F10a
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 9.59 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378093 | — | — | 1 | 10.52 |
| CHEMBL211410 | — | — | 1 | 10.40 |
| CHEMBL386294 | — | — | 1 | 9.96 |
| CHEMBL378222 | — | — | 1 | 9.92 |
| CHEMBL436791 | — | — | 1 | 9.89 |
| CHEMBL378092 | — | — | 1 | 9.82 |
| CHEMBL263767 | — | — | 1 | 9.80 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 9.72 |
| CHEMBL213888 | — | — | 1 | 9.66 |
| CHEMBL402881 | — | — | 1 | 9.62 |
| CHEMBL212770 | — | — | 1 | 9.60 |
| CHEMBL381949 | — | — | 1 | 9.59 |
| CHEMBL380405 | — | — | 1 | 9.57 |
| CHEMBL379588 | — | — | 1 | 9.51 |
| CHEMBL209376 | — | — | 1 | 9.47 |
| CHEMBL379397 | — | — | 1 | 9.47 |
| CHEMBL428982 | — | — | 1 | 9.46 |
| CHEMBL385679 | — | — | 1 | 9.26 |
| CHEMBL209483 | — | — | 1 | 9.22 |
| CHEMBL377589 | — | — | 1 | 9.22 |
| CHEMBL212202 | — | — | 1 | 9.19 |
| CHEMBL265087 | — | — | 1 | 9.15 |
| CHEMBL210175 | — | — | 1 | 9.09 |
| CHEMBL209916 | — | — | 1 | 9.07 |
| CHEMBL213252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378093 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL211410 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL386294 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL378222 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL436791 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL378092 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL263767 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL206335 | RAZAXABAN | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL213888 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL402881 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL212770 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL381949 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL380405 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL379588 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL209376 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL379397 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL428982 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL385679 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL209483 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL377589 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL212202 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL265087 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL210175 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL209916 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL213252 | — | Ki | < | 0.1 | nM | - |