Assay Detail
Binding
CHEMBL868639
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Binding affinity to human F2a
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.94 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378093 | — | — | 1 | 7.46 |
| CHEMBL211410 | — | — | 1 | 7.37 |
| CHEMBL378092 | — | — | 1 | 7.24 |
| CHEMBL213252 | — | — | 1 | 7.24 |
| CHEMBL378222 | — | — | 1 | 7.23 |
| CHEMBL213888 | — | — | 1 | 7.15 |
| CHEMBL263767 | — | — | 1 | 7.14 |
| CHEMBL436791 | — | — | 1 | 7.12 |
| CHEMBL386294 | — | — | 1 | 7.01 |
| CHEMBL379588 | — | — | 1 | 6.92 |
| CHEMBL428982 | — | — | 1 | 6.89 |
| CHEMBL380405 | — | — | 1 | 6.89 |
| CHEMBL209376 | — | — | 1 | 6.82 |
| CHEMBL265087 | — | — | 1 | 6.64 |
| CHEMBL379397 | — | — | 1 | 6.60 |
| CHEMBL212202 | — | — | 1 | 6.55 |
| CHEMBL385679 | — | — | 1 | 6.42 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378093 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL211410 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL378092 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL213252 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL378222 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL213888 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL263767 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL436791 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL386294 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL379588 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL428982 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL380405 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL209376 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL265087 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL379397 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL212202 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL385679 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL206335 | RAZAXABAN | Ki | = | 540.0 | nM | 6.27 |