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Assay Detail

CHEMBL868656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin D2 receptor 2 (CHEMBL5071)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent CRTh2 (DP2) receptor antagonists.
Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, Weaver R.
Bioorg Med Chem Lett (2006) 16 : 4287 -4290
PubMed 16753296 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.63 8.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378730 1 8.64
CHEMBL209689 1 8.59
CHEMBL214304 1 8.27
CHEMBL214350 1 8.22
CHEMBL213854 1 8.15
CHEMBL212777 1 8.10
CHEMBL211631 1 7.96
CHEMBL211677 1 7.75
CHEMBL213495 1 7.75
CHEMBL378666 1 7.68
CHEMBL213494 1 7.64
CHEMBL379828 1 7.30
CHEMBL384962 1 7.17
CHEMBL378094 1 6.90
CHEMBL213029 1 6.75
CHEMBL379639 1 5.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378730 IC50 = 2.3 nM 8.64
CHEMBL209689 IC50 = 2.6 nM 8.59
CHEMBL214304 IC50 = 5.4 nM 8.27
CHEMBL214350 IC50 = 6.0 nM 8.22
CHEMBL213854 IC50 = 7.1 nM 8.15
CHEMBL212777 IC50 = 8.0 nM 8.10
CHEMBL211631 IC50 = 11.0 nM 7.96
CHEMBL211677 IC50 = 18.0 nM 7.75
CHEMBL213495 IC50 = 18.0 nM 7.75
CHEMBL378666 IC50 = 21.0 nM 7.68
CHEMBL213494 IC50 = 23.0 nM 7.64
CHEMBL379828 IC50 = 50.0 nM 7.30
CHEMBL384962 IC50 = 68.0 nM 7.17
CHEMBL378094 IC50 = 125.0 nM 6.90
CHEMBL213029 IC50 = 180.0 nM 6.75
CHEMBL379639 IC50 = 5200.0 nM 5.28