Assay Detail
Binding
CHEMBL868697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cells
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 9.15 | 9.80 |
| Log Ki | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198860 | — | — | 1 | 9.80 |
| CHEMBL200366 | — | — | 1 | 9.60 |
| CHEMBL199080 | — | — | 1 | 9.60 |
| CHEMBL200580 | — | — | 1 | 9.40 |
| CHEMBL196817 | — | — | 1 | 9.40 |
| CHEMBL43116 | — | — | 1 | 9.27 |
| CHEMBL200839 | — | — | 1 | 9.25 |
| CHEMBL197442 | — | — | 1 | 9.10 |
| CHEMBL382972 | — | — | 1 | 9.10 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 9.09 |
| CHEMBL200446 | CLOPENPHENDIOXAN | — | 1 | 9.00 |
| CHEMBL427552 | — | — | 1 | 8.70 |
| CHEMBL200136 | — | — | 1 | 8.60 |
| CHEMBL198431 | — | — | 1 | 8.20 |
| CHEMBL199077 | — | — | 1 | - |
| CHEMBL200777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198860 | — | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL200366 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL199080 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL200580 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL196817 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL43116 | — | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL200839 | — | Ki | = | 0.5623 | nM | 9.25 |
| CHEMBL197442 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL382972 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 0.8128 | nM | 9.09 |
| CHEMBL200446 | CLOPENPHENDIOXAN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL427552 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL200136 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL198431 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL199077 | — | Log Ki | - | — | - | |
| CHEMBL200777 | — | Log Ki | - | — | - |