Assay Detail
Functional
CHEMBL868725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporter
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.34 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 11.00 |
| CHEMBL371012 | — | — | 1 | 7.42 |
| CHEMBL200799 | — | — | 1 | 6.61 |
| CHEMBL199599 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL371012 | — | EC50 | = | 38.5 | nM | 7.42 |
| CHEMBL200799 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL199599 | — | EC50 | > | 1000.0 | nM | - |