Assay Detail
Functional
CHEMBL868852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against Akt1 overexpressing murine FL5.12-Akt1 cell
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.15 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 6.54 |
| CHEMBL383264 | — | — | 1 | 6.38 |
| CHEMBL383541 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL383264 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL383541 | — | IC50 | = | 3000.0 | nM | 5.52 |