Assay Detail
ADMET
CHEMBL869054
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Inhibition of rat liver CYP3A1/3A2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.23 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536056 | — | — | 1 | 5.50 |
| CHEMBL541899 | — | — | 1 | 5.40 |
| CHEMBL537200 | — | — | 1 | 5.23 |
| CHEMBL552550 | — | — | 1 | 5.16 |
| CHEMBL535613 | — | — | 1 | 5.10 |
| CHEMBL535614 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536056 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL541899 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL537200 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL552550 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL535613 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL535614 | — | IC50 | = | 10000.0 | nM | 5.00 |