Assay Detail
Binding
CHEMBL869109
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Inhibition of Escherichia coli TEM1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.39 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212163 | — | — | 1 | 9.40 |
| CHEMBL379856 | — | — | 1 | 9.00 |
| CHEMBL378119 | — | — | 1 | 9.00 |
| CHEMBL212760 | — | — | 1 | 9.00 |
| CHEMBL380061 | — | — | 1 | 9.00 |
| CHEMBL385593 | — | — | 1 | 8.70 |
| CHEMBL378041 | — | — | 1 | 8.70 |
| CHEMBL425963 | — | — | 1 | 8.52 |
| CHEMBL377382 | — | — | 1 | 8.40 |
| CHEMBL212478 | — | — | 1 | 8.40 |
| CHEMBL379440 | — | — | 1 | 8.30 |
| CHEMBL377001 | — | — | 1 | 8.22 |
| CHEMBL211143 | — | — | 1 | 8.00 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.00 |
| CHEMBL211889 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212163 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL379856 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL378119 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212760 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL380061 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL385593 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL378041 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL425963 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL377382 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL212478 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL379440 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL377001 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL211143 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL211889 | — | IC50 | = | 730.0 | nM | 6.14 |