Assay Detail
Binding
CHEMBL869110
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Inhibition of Enterobacter cloacae Imi1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Imipenem-hydrolyzing beta-lactamase (CHEMBL4314) ↗| Type | SINGLE PROTEIN |
| Organism | Enterobacter cloacae |
Publication
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.31 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212163 | — | — | 1 | 8.10 |
| CHEMBL380061 | — | — | 1 | 8.05 |
| CHEMBL212760 | — | — | 1 | 7.75 |
| CHEMBL377382 | — | — | 1 | 7.70 |
| CHEMBL212478 | — | — | 1 | 7.66 |
| CHEMBL378041 | — | — | 1 | 7.57 |
| CHEMBL379440 | — | — | 1 | 7.55 |
| CHEMBL211143 | — | — | 1 | 7.40 |
| CHEMBL378119 | — | — | 1 | 7.25 |
| CHEMBL385593 | — | — | 1 | 7.05 |
| CHEMBL379856 | — | — | 1 | 6.91 |
| CHEMBL377001 | — | — | 1 | 6.38 |
| CHEMBL425963 | — | — | 1 | 5.64 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | - |
| CHEMBL211889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212163 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL380061 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL212760 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL377382 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL212478 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL378041 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL379440 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL211143 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL378119 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL385593 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL379856 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL377001 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL425963 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL404 | TAZOBACTAM | IC50 | - | — | - | |
| CHEMBL211889 | — | IC50 | > | 10000.0 | nM | - |