Assay Detail
Binding
CHEMBL869159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IMPDH1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 1 (CHEMBL1822) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384114 | — | — | 1 | 7.70 |
| CHEMBL215311 | — | — | 1 | 7.06 |
| CHEMBL410744 | — | — | 1 | 6.48 |
| CHEMBL2311206 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384114 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL215311 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL410744 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL2311206 | — | Ki | = | 520.0 | nM | 6.28 |