Assay Detail
Binding
CHEMBL869171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Methanobacterium thermoautotrophicum ODCase at 55 degreeC by competitive binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Methanobacterium thermoautotrophicum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Orotidine 5'-phosphate decarboxylase (CHEMBL5688) ↗| Type | SINGLE PROTEIN |
| Organism | Methanobacterium thermoautotrophicum |
Publication
Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.18 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514137 | — | — | 1 | 6.08 |
| CHEMBL463480 | 6-AZA-URIDINE MONOPHOSPHATE | — | 1 | 4.91 |
| CHEMBL512577 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514137 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL463480 | 6-AZA-URIDINE MONOPHOSPHATE | Ki | = | 12400.0 | nM | 4.91 |
| CHEMBL512577 | — | Ki | = | 29000.0 | nM | 4.54 |