Assay Detail
Functional
CHEMBL869193
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Similar structure-activity relationships of quinoline derivatives for antiprion and antimalarial effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.22 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214434 | — | — | 1 | 8.07 |
| CHEMBL315677 | — | — | 1 | 7.95 |
| CHEMBL153430 | — | — | 1 | 7.94 |
| CHEMBL87110 | — | — | 1 | 7.82 |
| CHEMBL89645 | — | — | 1 | 7.78 |
| CHEMBL150645 | — | — | 1 | 7.78 |
| CHEMBL86727 | — | — | 1 | 7.77 |
| CHEMBL356005 | — | — | 1 | 7.70 |
| CHEMBL149751 | — | — | 1 | 7.70 |
| CHEMBL422682 | — | — | 1 | 7.70 |
| CHEMBL152266 | — | — | 1 | 7.68 |
| CHEMBL89861 | — | — | 1 | 7.58 |
| CHEMBL378518 | — | — | 1 | 7.56 |
| CHEMBL405238 | — | — | 1 | 7.49 |
| CHEMBL152229 | — | — | 1 | 7.42 |
| CHEMBL213431 | — | — | 1 | 7.37 |
| CHEMBL359359 | — | — | 1 | 7.31 |
| CHEMBL425619 | — | — | 1 | 7.26 |
| CHEMBL152059 | — | — | 1 | 7.20 |
| CHEMBL86622 | — | — | 1 | 7.16 |
| CHEMBL42527 | — | — | 1 | 7.12 |
| CHEMBL384639 | — | — | 1 | 7.11 |
| CHEMBL356238 | — | — | 1 | 7.09 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.96 |
| CHEMBL90157 | — | — | 1 | 6.95 |
| CHEMBL357028 | — | — | 1 | 6.95 |
| CHEMBL407484 | — | — | 1 | 6.95 |
| CHEMBL152052 | — | — | 1 | 6.85 |
| CHEMBL46524 | — | — | 1 | 6.85 |
| CHEMBL298436 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214434 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL315677 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL153430 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL87110 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL89645 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL150645 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL86727 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL356005 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL149751 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL422682 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL152266 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL89861 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL378518 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL405238 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL152229 | — | IC50 | = | 38.2 | nM | 7.42 |
| CHEMBL213431 | — | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL359359 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL425619 | — | IC50 | = | 54.8 | nM | 7.26 |
| CHEMBL152059 | — | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL86622 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL42527 | — | IC50 | = | 75.4 | nM | 7.12 |
| CHEMBL384639 | — | IC50 | = | 76.9 | nM | 7.11 |
| CHEMBL356238 | — | IC50 | = | 80.6 | nM | 7.09 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL90157 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL357028 | — | IC50 | = | 112.1 | nM | 6.95 |
| CHEMBL407484 | — | IC50 | = | 112.8 | nM | 6.95 |
| CHEMBL152052 | — | IC50 | = | 142.1 | nM | 6.85 |
| CHEMBL46524 | — | IC50 | = | 142.1 | nM | 6.85 |
| CHEMBL298436 | — | IC50 | = | 152.2 | nM | 6.82 |
| CHEMBL152553 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL86739 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL86583 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL215410 | — | IC50 | = | 204.7 | nM | 6.69 |
| CHEMBL345264 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL213095 | — | IC50 | = | 260.5 | nM | 6.58 |
| CHEMBL215570 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL385657 | — | IC50 | = | 390.9 | nM | 6.41 |
| CHEMBL264351 | — | IC50 | = | 395.7 | nM | 6.40 |
| CHEMBL45031 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL297227 | — | IC50 | > | 1000.0 | nM | - |