Assay Detail
Functional
CHEMBL869245
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Inhibition of MCP1-stimulated chemotaxis of human monocyte
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.12 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213601 | — | — | 1 | 7.39 |
| CHEMBL373491 | — | — | 1 | 7.21 |
| CHEMBL277279 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213601 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL373491 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL277279 | — | IC50 | = | 176.0 | nM | 6.75 |