Assay Detail
Binding
CHEMBL869256
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Inhibition of rat brain AChE
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.40 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 8.82 |
| CHEMBL73800 | — | — | 1 | 8.42 |
| CHEMBL75274 | — | — | 1 | 8.11 |
| CHEMBL179732 | — | — | 1 | 7.55 |
| CHEMBL424707 | — | — | 1 | 7.51 |
| CHEMBL386423 | — | — | 1 | 7.40 |
| CHEMBL211313 | — | — | 1 | 6.80 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.65 |
| CHEMBL378006 | — | — | 1 | 6.59 |
| CHEMBL213377 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL73800 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL75274 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL179732 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL424707 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL386423 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL211313 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL95 | TACRINE | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL378006 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL213377 | — | IC50 | = | 711.0 | nM | 6.15 |