Assay Detail
Binding
CHEMBL869257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat serum BuChE
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.83 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.04 |
| CHEMBL213377 | — | — | 1 | 6.99 |
| CHEMBL75274 | — | — | 1 | 6.98 |
| CHEMBL73800 | — | — | 1 | 6.92 |
| CHEMBL32823 | — | — | 1 | 6.83 |
| CHEMBL378006 | — | — | 1 | 6.82 |
| CHEMBL424707 | — | — | 1 | 6.81 |
| CHEMBL386423 | — | — | 1 | 6.78 |
| CHEMBL211313 | — | — | 1 | 6.60 |
| CHEMBL179732 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL213377 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL75274 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL73800 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL32823 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL378006 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL424707 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL386423 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL211313 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL179732 | — | IC50 | = | 329.0 | nM | 6.48 |