Assay Detail
Binding
CHEMBL869275
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Inhibition of rat FAS
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.38 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212547 | — | — | 1 | 7.30 |
| CHEMBL380035 | — | — | 1 | 7.14 |
| CHEMBL378610 | — | — | 1 | 7.07 |
| CHEMBL379396 | — | — | 1 | 6.91 |
| CHEMBL214763 | — | — | 1 | 6.87 |
| CHEMBL214764 | — | — | 1 | 6.76 |
| CHEMBL211838 | — | — | 1 | 6.76 |
| CHEMBL437299 | — | — | 1 | 6.35 |
| CHEMBL413773 | — | — | 1 | 6.26 |
| CHEMBL378095 | — | — | 1 | 6.16 |
| CHEMBL212778 | — | — | 1 | 5.58 |
| CHEMBL377646 | — | — | 1 | 5.52 |
| CHEMBL214353 | — | — | 1 | 5.47 |
| CHEMBL212823 | — | — | 1 | 5.22 |
| CHEMBL213299 | — | — | 1 | - |
| CHEMBL209582 | — | — | 1 | - |
| CHEMBL213458 | — | — | 1 | - |
| CHEMBL377915 | — | — | 1 | - |
| CHEMBL209897 | — | — | 1 | - |
| CHEMBL209576 | — | — | 1 | - |
| CHEMBL209733 | — | — | 1 | - |
| CHEMBL324519 | — | — | 1 | - |
| CHEMBL209656 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212547 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL380035 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL378610 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL379396 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL214763 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL214764 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL211838 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL437299 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL413773 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL378095 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL212778 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL377646 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL214353 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL212823 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL213299 | — | IC50 | - | — | - | |
| CHEMBL209582 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL213458 | — | IC50 | - | — | - | |
| CHEMBL377915 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL209897 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL209576 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL209733 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL324519 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL209656 | — | IC50 | - | — | - |