Assay Detail
Functional
CHEMBL869299
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Antiproliferative activity against human A375 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.36 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.35 |
| CHEMBL378248 | — | — | 1 | 5.03 |
| CHEMBL209280 | — | — | 1 | 4.69 |
| CHEMBL212264 | — | — | 1 | - |
| CHEMBL379193 | — | — | 1 | - |
| CHEMBL210581 | — | — | 1 | - |
| CHEMBL210765 | — | — | 1 | - |
| CHEMBL378420 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL378248 | — | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL209280 | — | IC50 | = | 20250.0 | nM | 4.69 |
| CHEMBL212264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL379193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL210581 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210765 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL378420 | — | IC50 | > | 100000.0 | nM | - |