Assay Detail
Functional
CHEMBL869349
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Antiproliferative activity against wild type p53 MCF7 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.93 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208562 | — | — | 1 | 6.10 |
| CHEMBL210545 | — | — | 1 | 5.96 |
| CHEMBL377203 | — | — | 1 | 5.89 |
| CHEMBL207364 | — | — | 1 | 5.77 |
| CHEMBL377614 | — | — | 1 | - |
| CHEMBL425780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208562 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL210545 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL377203 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL207364 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL377614 | — | IC50 | 16000.0 | nM | - | |
| CHEMBL425780 | — | IC50 | - | — | - |