Assay Detail
Functional
CHEMBL869350
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Antiproliferative activity against mutant p53 MDA-MB-231 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.69 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208562 | — | — | 1 | 5.10 |
| CHEMBL377203 | — | — | 1 | 5.00 |
| CHEMBL207364 | — | — | 1 | 5.00 |
| CHEMBL210545 | — | — | 1 | 4.24 |
| CHEMBL377614 | — | — | 1 | 4.10 |
| CHEMBL425780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208562 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL377203 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL207364 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL210545 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL377614 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL425780 | — | IC50 | - | — | - |