Assay Detail
Binding
CHEMBL869401
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Inhibition of recombinant human cytosolic isozyme CA I
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.58 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 8.68 |
| CHEMBL122708 | EMATE | — | 1 | 7.43 |
| CHEMBL1628004 | — | — | 1 | 7.02 |
| CHEMBL198913 | — | — | 1 | 7.01 |
| CHEMBL1628081 | — | — | 1 | 6.94 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL370854 | — | — | 1 | 6.56 |
| CHEMBL371870 | PHENYLDIFLUOROMETHANESULFONAMIDE | — | 1 | 6.45 |
| CHEMBL198891 | — | — | 1 | 6.38 |
| CHEMBL199464 | — | — | 1 | 6.02 |
| CHEMBL200673 | — | — | 1 | 5.96 |
| CHEMBL370159 | — | — | 1 | 5.95 |
| CHEMBL369953 | PHENYLMETHANESULFONAMIDE | — | 1 | 5.90 |
| CHEMBL199493 | — | — | 1 | 5.28 |
| CHEMBL11185 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24259 | PHENYLSULFAMATE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL122708 | EMATE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1628004 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL198913 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL1628081 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL370854 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL371870 | PHENYLDIFLUOROMETHANESULFONAMIDE | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL198891 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL199464 | — | Ki | = | 952.0 | nM | 6.02 |
| CHEMBL200673 | — | Ki | = | 1095.0 | nM | 5.96 |
| CHEMBL370159 | — | Ki | = | 1130.0 | nM | 5.95 |
| CHEMBL369953 | PHENYLMETHANESULFONAMIDE | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL199493 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL11185 | — | Ki | - | — | - |