Assay Detail
Binding
CHEMBL869436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DNA gyrase supercoiling in Escherichia coli ATCC 25922
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.89 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200962 | — | — | 1 | 6.70 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.52 |
| CHEMBL201369 | — | — | 1 | 6.40 |
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | 6.22 |
| CHEMBL201439 | — | — | 1 | 4.85 |
| CHEMBL199517 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200962 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL201369 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL9 | NORFLOXACIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL201439 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL199517 | — | IC50 | = | 24000.0 | nM | 4.62 |