Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL869446

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to adrenergic alpha-1 receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL2094251)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.
Kumar JS, Majo VJ, Hsiung SC, Millak MS, Liu KP, Tamir H, Prabhakaran J, Simpson NR, Van Heertum RL, Mann JJ, Parsey RV.
J Med Chem (2006) 49 : 125 -134
PubMed 16392798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.49 7.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL199824 1 7.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL199824 Ki = 32.2 nM 7.49