Assay Detail

CHEMBL869617

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Functional

Antiviral activity against multi PI resistant HIV1 31246 in MT4 cells

ChEMBL ↗

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Target

MT4 (CHEMBL388) ↗

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Primary target MT4

CHEMBL388

Anchored from Assay target.

Protein identity MT4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Cell Type	MT4
Confidence	1 — Organism
Curated By	Expert

Target

MT4 (CHEMBL388) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.

Miller JF, Andrews CW, Brieger M, Furfine ES, Hale MR, Hanlon MH, Hazen RJ, Kaldor I, McLean EW, Reynolds D, Sammond DM, Spaltenstein A, Tung R, Turner EM, Xu RX, Sherrill RG.
Bioorg Med Chem Lett (2006) 16 : 1788 -1794
PubMed 16458505 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.77	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL206031	BRECANAVIR	2.0	1	8.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL206031	BRECANAVIR	IC50	=	1.7	nM	8.77