Assay Detail
Binding
CHEMBL869624
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Binding affinity to rat EP2 receptor expressed in HEK293 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL4909) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.45 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425243 | — | — | 1 | 7.07 |
| CHEMBL379785 | — | — | 1 | 6.90 |
| CHEMBL382197 | — | — | 1 | 6.87 |
| CHEMBL379746 | — | — | 1 | 6.73 |
| CHEMBL378376 | — | — | 1 | 6.32 |
| CHEMBL378968 | — | — | 1 | 6.19 |
| CHEMBL382029 | — | — | 1 | 6.16 |
| CHEMBL207237 | — | — | 1 | 5.92 |
| CHEMBL425950 | — | — | 1 | 5.92 |
| CHEMBL208411 | — | — | 1 | - |
| CHEMBL46395 | — | — | 1 | - |
| CHEMBL380839 | — | — | 1 | - |
| CHEMBL425409 | — | — | 1 | - |
| CHEMBL203076 | — | — | 1 | - |
| CHEMBL205819 | — | — | 1 | - |
| CHEMBL383339 | — | — | 1 | - |
| CHEMBL208510 | — | — | 1 | - |
| CHEMBL206774 | — | — | 1 | - |
| CHEMBL381755 | — | — | 1 | - |
| CHEMBL208399 | — | — | 1 | - |
| CHEMBL383515 | — | — | 1 | - |
| CHEMBL203780 | — | — | 1 | - |
| CHEMBL204058 | — | — | 1 | - |
| CHEMBL208407 | — | — | 1 | - |
| CHEMBL2113220 | — | — | 1 | - |
| CHEMBL208410 | — | — | 1 | - |
| CHEMBL208080 | — | — | 1 | - |
| CHEMBL444798 | — | — | 1 | - |
| CHEMBL427035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425243 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL379785 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL382197 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL379746 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL378376 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL378968 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL382029 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL207237 | — | IC50 | = | 1205.0 | nM | 5.92 |
| CHEMBL425950 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL208411 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL46395 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL380839 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL425409 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL203076 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL205819 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL383339 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL208510 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL206774 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL381755 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL208399 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL383515 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL203780 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL204058 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL208407 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL2113220 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL208410 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL208080 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL444798 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL427035 | — | IC50 | > | 3200.0 | nM | - |