Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL869686

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL ↗
153
Total Activities
153
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 9 — Direct single protein target
Curated By Expert

Target

Alpha-1D adrenergic receptor (CHEMBL326) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Vasorelaxant activity of phthalazinones and related compounds.
del Olmo E, Barboza B, Ybarra MI, López-Pérez JL, Carrón R, Sevilla MA, Boselli C, San Feliciano A.
Bioorg Med Chem Lett (2006) 16 : 2786 -2790
PubMed 16513345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 153 5.52 6.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67457 — — 1 6.37
CHEMBL63976 — — 1 6.10
CHEMBL206101 — — 1 6.03
CHEMBL68362 — — 1 6.03
CHEMBL207779 — — 1 5.92
CHEMBL209043 — — 1 5.89
CHEMBL207120 — — 1 5.85
CHEMBL378274 — — 1 5.72
CHEMBL67126 — — 1 5.66
CHEMBL207277 — — 1 5.58
CHEMBL66433 — — 1 5.54
CHEMBL68230 — — 1 5.43
CHEMBL207189 — — 1 5.36
CHEMBL204632 — — 1 5.31
CHEMBL207325 — — 1 5.28
CHEMBL379270 — — 1 5.27
CHEMBL376932 — — 1 5.26
CHEMBL207170 — — 1 5.01
CHEMBL207846 — — 1 5.00
CHEMBL377068 — — 1 4.85
CHEMBL208355 — — 1 4.54
CHEMBL66761 — — 1 -
CHEMBL207767 — — 1 -
CHEMBL308666 — — 1 -
CHEMBL293674 — — 1 -
CHEMBL304747 — — 1 -
CHEMBL207546 — — 1 -
CHEMBL378487 — — 1 -
CHEMBL207714 — — 1 -
CHEMBL307117 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67457 — EC50 = 430.0 nM 6.37
CHEMBL63976 — EC50 = 790.0 nM 6.10
CHEMBL206101 — EC50 = 930.0 nM 6.03
CHEMBL68362 — EC50 = 930.0 nM 6.03
CHEMBL207779 — EC50 = 1200.0 nM 5.92
CHEMBL209043 — EC50 = 1300.0 nM 5.89
CHEMBL207120 — EC50 = 1400.0 nM 5.85
CHEMBL378274 — EC50 = 1900.0 nM 5.72
CHEMBL67126 — EC50 = 2200.0 nM 5.66
CHEMBL207277 — EC50 = 2600.0 nM 5.58
CHEMBL66433 — EC50 = 2900.0 nM 5.54
CHEMBL68230 — EC50 = 3700.0 nM 5.43
CHEMBL207189 — EC50 = 4400.0 nM 5.36
CHEMBL204632 — EC50 = 4900.0 nM 5.31
CHEMBL207325 — EC50 = 5300.0 nM 5.28
CHEMBL379270 — EC50 = 5400.0 nM 5.27
CHEMBL376932 — EC50 = 5500.0 nM 5.26
CHEMBL207170 — EC50 = 9800.0 nM 5.01
CHEMBL207846 — EC50 = 10000.0 nM 5.00
CHEMBL377068 — EC50 = 14000.0 nM 4.85
CHEMBL208355 — EC50 = 29000.0 nM 4.54
CHEMBL380491 — EC50 - — -
CHEMBL381795 — EC50 - — -
CHEMBL207264 — EC50 - — -
CHEMBL380079 — EC50 - — -
CHEMBL206836 — EC50 - — -
CHEMBL207865 — EC50 - — -
CHEMBL206094 — EC50 - — -
CHEMBL206095 — EC50 - — -
CHEMBL208209 — EC50 - — -
CHEMBL208044 — EC50 - — -
CHEMBL207507 — EC50 - — -
CHEMBL378862 — EC50 - — -
CHEMBL207761 — EC50 - — -
CHEMBL382438 — EC50 - — -
CHEMBL208045 — EC50 - — -
CHEMBL207017 — EC50 - — -
CHEMBL207517 — EC50 - — -
CHEMBL210326 — EC50 - — -
CHEMBL382250 — EC50 - — -
CHEMBL207416 — EC50 - — -
CHEMBL207254 — EC50 - — -
CHEMBL207474 — EC50 - — -
CHEMBL209092 — EC50 - — -
CHEMBL377795 — EC50 - — -
CHEMBL208188 — EC50 - — -
CHEMBL207258 — EC50 - — -
CHEMBL377494 — EC50 - — -
CHEMBL381494 — EC50 - — -
CHEMBL378452 — EC50 - — -