Compound Detail
CHEMBL63976
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Basic Information
| ChEMBL ID | CHEMBL63976 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NLXGCQIEVZYDRS-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
270.7
MW (Da)
3.58
ALogP
3
HBA
1
HBD
46.0
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.1
IC50 1 meas. best 4.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-1D adrenergic receptor CHEMBL326 | EC50 | 6.1 | 6.1 | 790.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | EC50 | 5.41 | 5.41 | 3900.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.66 | 4.66 | 22000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-1D adrenergic receptor | EC50 | = | 790.0 | nM | 6.1 | Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction | 16513345 |
| Alpha-1A adrenergic receptor | EC50 | = | 3900.0 | nM | 5.41 | Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction | 16513345 |
| Plasmodium falciparum | IC50 | = | 22000.0 | nM | 4.66 | In vitro inhibitory concentration against Plasmodium falciparum F32 | 12873511 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16513345 | 10.1016/j.bmcl.2006.02.003 | Alpha-1A adrenergic receptor | 4 |
| 12873511 | 10.1016/s0960-894x(03)00509-2 | Plasmodium falciparum | 3 |
| 11591517 | 10.1016/s0960-894x(01)00562-5 | Trypanosoma cruzi | 2 |
| 16513345 | 10.1016/j.bmcl.2006.02.003 | Alpha-1D adrenergic receptor | 2 |
| 11514152 | 10.1016/s0960-894x(01)00387-0 | Leishmania braziliensis | 1 |
| 11514152 | 10.1016/s0960-894x(01)00387-0 | Leishmania amazonensis | 1 |
| 11514152 | 10.1016/s0960-894x(01)00387-0 | Leishmania donovani | 1 |
Data from ChEMBL 36 via Core Engine