Assay Detail
Functional
CHEMBL869736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at alpha7-5HT3 chimera expressed in SHEP1 cells by FLIPR assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SHEP1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.86 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378471 | — | — | 1 | 7.33 |
| CHEMBL378349 | — | — | 1 | 7.32 |
| CHEMBL208565 | — | — | 1 | 7.26 |
| CHEMBL214268 | PHA-543613 | 1.0 | 1 | 7.19 |
| CHEMBL378496 | — | — | 1 | 7.11 |
| CHEMBL268939 | — | — | 1 | 7.09 |
| CHEMBL379302 | — | — | 1 | 7.07 |
| CHEMBL210865 | — | — | 1 | 7.00 |
| CHEMBL212669 | — | — | 1 | 7.00 |
| CHEMBL177611 | PNU-282987 | — | 1 | 6.89 |
| CHEMBL214195 | — | — | 1 | 6.43 |
| CHEMBL377036 | — | — | 1 | 6.26 |
| CHEMBL211572 | — | — | 1 | 6.22 |
| CHEMBL377032 | — | — | 1 | 5.93 |
| CHEMBL214243 | — | — | 1 | - |
| CHEMBL375776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378471 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL378349 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL208565 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL214268 | PHA-543613 | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL378496 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL268939 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL379302 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL210865 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL212669 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL177611 | PNU-282987 | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL214195 | — | EC50 | = | 374.0 | nM | 6.43 |
| CHEMBL377036 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL211572 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL377032 | — | EC50 | = | 1173.0 | nM | 5.93 |
| CHEMBL214243 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL375776 | — | EC50 | > | 10000.0 | nM | - |