Assay Detail
Functional
CHEMBL869771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in MT4 cells
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.91 | 8.52 |
| IC50 | 2 | 6.47 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210396 | — | — | 1 | 8.52 |
| CHEMBL379382 | — | — | 1 | 7.96 |
| CHEMBL378395 | — | — | 1 | 7.16 |
| CHEMBL209440 | — | — | 1 | 7.05 |
| CHEMBL211634 | — | — | 1 | 7.00 |
| CHEMBL211275 | — | — | 1 | 6.47 |
| CHEMBL377693 | — | — | 1 | 6.11 |
| CHEMBL212320 | — | — | 1 | 5.93 |
| CHEMBL212921 | — | — | 1 | 5.12 |
| CHEMBL209591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210396 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL379382 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL378395 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL209440 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL211634 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL211275 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL377693 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL212320 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL212921 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL209591 | — | EC50 | > | 10000.0 | nM | - |