Assay Detail
Functional
CHEMBL869774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B assessed as protein binding effect in MT2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.12 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209854 | — | — | 1 | 7.27 |
| CHEMBL414850 | — | — | 1 | 7.06 |
| CHEMBL211110 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209854 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL414850 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL211110 | — | EC50 | = | 94.0 | nM | 7.03 |