Assay Detail
Binding
CHEMBL869784
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Inhibition of wild type PTP1B
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.85 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139393 | — | — | 1 | 5.22 |
| CHEMBL138152 | — | — | 1 | 4.47 |
| CHEMBL377471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139393 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL138152 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL377471 | — | Ki | > | 300000.0 | nM | - |