Assay Detail
Binding
CHEMBL869785
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Inhibition of PTP1B I219A mutant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.88 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139393 | — | — | 1 | 6.64 |
| CHEMBL138152 | — | — | 1 | 6.00 |
| CHEMBL377471 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139393 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL138152 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL377471 | — | Ki | = | 10000.0 | nM | 5.00 |