Assay Detail
Functional
CHEMBL869799
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Spasmolytic activity in Wistar rat ileum
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, microwave-assisted synthesis, and spasmolytic activity of 2-(alkyloxyaryl)-1H-benzimidazole derivatives as constrained stilbene bioisosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.21 | 5.92 |
| Emax | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385136 | — | — | 2 | 5.92 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 2 | 5.81 |
| CHEMBL209913 | — | — | 2 | 5.76 |
| CHEMBL209470 | — | — | 2 | 5.75 |
| CHEMBL209734 | — | — | 2 | 5.72 |
| CHEMBL377207 | — | — | 2 | 5.71 |
| CHEMBL378887 | — | — | 2 | 5.47 |
| CHEMBL209200 | — | — | 2 | 5.40 |
| CHEMBL203360 | — | — | 2 | 5.29 |
| CHEMBL377740 | — | — | 2 | 5.28 |
| CHEMBL209469 | — | — | 2 | 5.25 |
| CHEMBL426871 | — | — | 2 | 5.23 |
| CHEMBL209369 | — | — | 2 | 5.11 |
| CHEMBL379179 | — | — | 2 | 4.97 |
| CHEMBL380245 | — | — | 2 | 4.82 |
| CHEMBL209552 | — | — | 2 | 4.55 |
| CHEMBL209544 | — | — | 2 | 4.52 |
| CHEMBL379880 | — | — | 2 | 4.23 |
| CHEMBL209918 | — | — | 2 | 4.11 |
| CHEMBL379376 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385136 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL209913 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL209470 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL209734 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL377207 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL378887 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL209200 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL203360 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL377740 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL209469 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL426871 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL209369 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL379179 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL380245 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL209552 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL209544 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL379880 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL209918 | — | IC50 | = | 78600.0 | nM | 4.11 |
| CHEMBL377207 | — | Emax | = | 50.0 | % | - |
| CHEMBL209734 | — | Emax | = | 80.0 | % | - |
| CHEMBL209552 | — | Emax | = | 51.4 | % | - |
| CHEMBL379880 | — | Emax | = | 38.2 | % | - |
| CHEMBL380245 | — | Emax | = | 47.7 | % | - |
| CHEMBL209918 | — | Emax | = | 11.1 | % | - |
| CHEMBL377740 | — | Emax | = | 61.2 | % | - |
| CHEMBL379179 | — | Emax | = | 54.9 | % | - |
| CHEMBL209369 | — | Emax | = | 52.8 | % | - |
| CHEMBL385136 | — | Emax | = | 70.0 | % | - |
| CHEMBL209469 | — | Emax | = | 55.0 | % | - |
| CHEMBL209470 | — | Emax | = | 65.0 | % | - |
| CHEMBL209200 | — | Emax | = | 90.0 | % | - |
| CHEMBL378887 | — | Emax | = | 59.0 | % | - |
| CHEMBL379376 | — | Emax | = | 50.0 | % | - |
| CHEMBL209913 | — | Emax | = | 60.0 | % | - |
| CHEMBL426871 | — | Emax | = | 93.5 | % | - |
| CHEMBL19224 | PAPAVERINE | Emax | = | 96.7 | % | - |
| CHEMBL209544 | — | Emax | = | 34.9 | % | - |
| CHEMBL203360 | — | Emax | = | 42.4 | % | - |
| CHEMBL379376 | — | IC50 | = | 190000.0 | nM | - |