Assay Detail
Binding
CHEMBL869801
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Binding affinity to human tryptase beta2
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.30 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211561 | — | — | 1 | 8.27 |
| CHEMBL212096 | — | — | 1 | 8.00 |
| CHEMBL426330 | — | — | 1 | 7.92 |
| CHEMBL208895 | — | — | 1 | 7.89 |
| CHEMBL215486 | — | — | 1 | 7.85 |
| CHEMBL212196 | — | — | 1 | 7.80 |
| CHEMBL212095 | — | — | 1 | 7.72 |
| CHEMBL210055 | — | — | 1 | 7.62 |
| CHEMBL209852 | — | — | 1 | 7.60 |
| CHEMBL380012 | — | — | 1 | 7.57 |
| CHEMBL265253 | — | — | 1 | 7.39 |
| CHEMBL211082 | — | — | 1 | 7.11 |
| CHEMBL377629 | — | — | 1 | 7.02 |
| CHEMBL214222 | — | — | 1 | 6.92 |
| CHEMBL210054 | — | — | 1 | 6.75 |
| CHEMBL383868 | — | — | 1 | 6.44 |
| CHEMBL210058 | — | — | 1 | 5.96 |
| CHEMBL214315 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211561 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL212096 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL426330 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL208895 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL215486 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL212196 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL212095 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL210055 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL209852 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL380012 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL265253 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL211082 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL377629 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL214222 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL210054 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL383868 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL210058 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL214315 | — | Ki | = | 2700.0 | nM | 5.57 |