Assay Detail
Binding
CHEMBL869864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit testis recombinant ACE C domain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.94 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 7.29 |
| CHEMBL385901 | — | — | 1 | 6.10 |
| CHEMBL435360 | — | — | 1 | 5.75 |
| CHEMBL213105 | — | — | 1 | 4.62 |
| CHEMBL212864 | — | — | 1 | - |
| CHEMBL215163 | — | — | 1 | - |
| CHEMBL386032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL385901 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL435360 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL213105 | — | Ki | = | 23700.0 | nM | 4.62 |
| CHEMBL212864 | — | Ki | = | 313000.0 | nM | - |
| CHEMBL215163 | — | Ki | = | 381300.0 | nM | - |
| CHEMBL386032 | — | Ki | = | 143500.0 | nM | - |