Assay Detail
Binding
CHEMBL869865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant ACE N domain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.84 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 6.88 |
| CHEMBL215163 | — | — | 1 | 4.88 |
| CHEMBL386032 | — | — | 1 | 4.47 |
| CHEMBL212864 | — | — | 1 | 4.37 |
| CHEMBL435360 | — | — | 1 | 4.34 |
| CHEMBL213105 | — | — | 1 | 4.07 |
| CHEMBL385901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | = | 131.5 | nM | 6.88 |
| CHEMBL215163 | — | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL386032 | — | Ki | = | 33600.0 | nM | 4.47 |
| CHEMBL212864 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL435360 | — | Ki | = | 45200.0 | nM | 4.34 |
| CHEMBL213105 | — | Ki | = | 84300.0 | nM | 4.07 |
| CHEMBL385901 | — | Ki | = | 195700.0 | nM | - |