Assay Detail
Functional
CHEMBL869898
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Agonist activity at delta opioid receptor assessed as inhibition of electrically-evoked contraction of mouse vas deferens
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.24 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.43 |
| CHEMBL3143818 | — | — | 1 | 5.04 |
| CHEMBL2028967 | — | — | 1 | - |
| CHEMBL3143821 | — | — | 1 | - |
| CHEMBL3143820 | — | — | 1 | - |
| CHEMBL3143819 | — | — | 1 | - |
| CHEMBL2028972 | — | — | 1 | - |
| CHEMBL2028971 | — | — | 1 | - |
| CHEMBL2028970 | — | — | 1 | - |
| CHEMBL2028969 | — | — | 1 | - |
| CHEMBL2028968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 0.371 | nM | 9.43 |
| CHEMBL3143818 | — | IC50 | = | 9049.0 | nM | 5.04 |
| CHEMBL2028967 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3143821 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3143820 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3143819 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028972 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028971 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028968 | — | IC50 | > | 10000.0 | nM | - |