Assay Detail
Functional
CHEMBL869901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor assessed as inhibition of electrically-evoked contraction of guinea pig ileum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.79 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 7.86 |
| CHEMBL3143821 | — | — | 1 | 7.40 |
| CHEMBL3143820 | — | — | 1 | 7.27 |
| CHEMBL3143819 | — | — | 1 | 7.20 |
| CHEMBL3143818 | — | — | 1 | 6.43 |
| CHEMBL2028970 | — | — | 1 | 6.36 |
| CHEMBL2028972 | — | — | 1 | 5.90 |
| CHEMBL2028971 | — | — | 1 | 5.90 |
| CHEMBL2028967 | — | — | 1 | - |
| CHEMBL2028969 | — | — | 1 | - |
| CHEMBL2028968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL3143821 | — | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL3143820 | — | IC50 | = | 53.9 | nM | 7.27 |
| CHEMBL3143819 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL3143818 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL2028970 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL2028972 | — | IC50 | = | 1254.0 | nM | 5.90 |
| CHEMBL2028971 | — | IC50 | = | 1248.0 | nM | 5.90 |
| CHEMBL2028967 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2028968 | — | IC50 | > | 10000.0 | nM | - |