Assay Detail
Functional
CHEMBL869905
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Antagonist activity at delta opioid receptor assessed as inhibition of deltorphin-2-induced contraction of mouse vas deferens
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.10 | 10.40 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028968 | — | — | 1 | 10.40 |
| CHEMBL2371927 | — | — | 1 | 8.85 |
| CHEMBL2028967 | — | — | 1 | 6.21 |
| CHEMBL2028969 | — | — | 1 | 6.01 |
| CHEMBL2028970 | — | — | 1 | 5.77 |
| CHEMBL2028972 | — | — | 1 | 5.38 |
| CHEMBL3143820 | — | — | 1 | - |
| CHEMBL3143819 | — | — | 1 | - |
| CHEMBL3143818 | — | — | 1 | - |
| CHEMBL2028971 | — | — | 1 | - |
| CHEMBL3143821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028968 | — | Kd | = | 0.03981 | nM | 10.40 |
| CHEMBL2371927 | — | Kd | = | 1.413 | nM | 8.85 |
| CHEMBL2028967 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL2028969 | — | Kd | = | 977.24 | nM | 6.01 |
| CHEMBL2028970 | — | Kd | = | 1698.24 | nM | 5.77 |
| CHEMBL2028972 | — | Kd | = | 4168.69 | nM | 5.38 |
| CHEMBL3143820 | — | Activity | - | — | - | |
| CHEMBL3143819 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL3143818 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL2028971 | — | Kd | = | 0.001 | nM | - |
| CHEMBL3143821 | — | Activity | - | — | - |