Assay Detail
Binding
CHEMBL870159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 17-beta-HSD2 expressed in HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.94 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207413 | ACETOXOLONE | -1.0 | 1 | 5.42 |
| CHEMBL206908 | — | — | 1 | 5.13 |
| CHEMBL382614 | — | — | 1 | 4.99 |
| CHEMBL380677 | — | — | 1 | 4.63 |
| CHEMBL211039 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207413 | ACETOXOLONE | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL206908 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL382614 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL380677 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL211039 | — | IC50 | = | 28300.0 | nM | 4.55 |