Assay Detail
Binding
CHEMBL870329
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Inhibition of Septoria nodorum succinate dehydrogenase and Qi site of mitochondrial respiratory chain complex 3 by FMET2-3 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Parastagonospora nodorum |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Mitochondrial complex II; succinate dehydrogenase (CHEMBL613815) ↗| Type | PROTEIN COMPLEX |
| Organism | Septoria tritici |
Publication
Potent inhibitors of the Qi site of the mitochondrial respiration complex III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211501 | ANTIMYCIN A | — | 1 | 8.70 |
| CHEMBL439507 | — | — | 1 | 8.30 |
| CHEMBL378123 | — | — | 1 | 7.58 |
| CHEMBL379116 | — | — | 1 | 7.58 |
| CHEMBL379557 | — | — | 1 | 7.50 |
| CHEMBL377384 | — | — | 1 | 6.90 |
| CHEMBL211246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211501 | ANTIMYCIN A | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL439507 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL378123 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL379116 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL379557 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL377384 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL211246 | — | IC50 | > | 30000.0 | nM | - |