Compound Detail
CHEMBL379116
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Basic Information
| ChEMBL ID | CHEMBL379116 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | URMGSJXLSFBNTA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
359.4
MW (Da)
4.62
ALogP
4
HBA
3
HBD
87.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitochondrial complex II; succinate dehydrogenase CHEMBL613815 | IC50 | 7.58 | 7.58 | 26.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitochondrial complex II; succinate dehydrogenase | IC50 | = | 26.0 | nM | 7.58 | Inhibition of Septoria nodorum succinate dehydrogenase and Qi site of mitochondr... | 16854082 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16854082 | 10.1021/jm060408s | Parastagonospora nodorum | 2 |
| 16854082 | 10.1021/jm060408s | Mitochondrial complex II; succinate dehydrogenase | 2 |
Data from ChEMBL 36 via Core Engine