Assay Detail
Binding
CHEMBL870484
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Displacement of [3H]muscimol from GABA-A receptor in Sprague-Dawley rat cerebral cortex
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.38 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.62 |
| CHEMBL213907 | THIOCOLCHICOSIDE | 3.0 | 1 | 5.47 |
| CHEMBL213015 | — | — | 1 | 5.27 |
| CHEMBL213312 | — | — | 1 | 5.16 |
| CHEMBL215655 | — | — | 1 | 5.01 |
| CHEMBL214151 | — | — | 1 | 4.98 |
| CHEMBL386430 | — | — | 1 | 4.75 |
| CHEMBL438794 | — | — | 1 | 4.75 |
| CHEMBL213034 | — | — | 1 | - |
| CHEMBL214305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL213907 | THIOCOLCHICOSIDE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL213015 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL213312 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL215655 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL214151 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL386430 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL438794 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL213034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL214305 | — | IC50 | > | 100000.0 | nM | - |