Assay Detail

CHEMBL870516

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Functional

Inhibition of MIP-1-beta-stimulated chemotaxis of human AlloT cells

ChEMBL ↗

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Target

T-cell (CHEMBL614309) ↗

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Primary target T-cell

CHEMBL614309

Anchored from Assay target.

Protein identity T-cell

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	T-cell
Confidence	1 — Organism
Curated By	Expert

Target

T-cell (CHEMBL614309) ↗

Type

CELL-LINE

Publication

Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.

Cumming JG, Brown SJ, Cooper AE, Faull AW, Flynn AP, Grime K, Oldfield J, Shaw JS, Shepherd E, Tucker H, Whittaker D.
Bioorg Med Chem Lett (2006) 16 : 3533 -3536
PubMed 16631366 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.55	8.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL212689	—	—	1	8.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL212689	—	IC50	=	2.8	nM	8.55